Lower extremity vascular disease:

Peripheral artery disease vs. deep venous thrombosis: PERIPHERAL ARTERY DISEASE (PAD).- Due to arterial stenosis. Associated with heavy and prolonged tobacco use and atherosclerotic disease. Reduce blood flow will cause signs and symptoms such as weak pulses, pallor, cold skin, ulceration and of course lower extremity pain that increases with exertion up to the point…

Thrombotic microangiopathy and hemolytic anemia:

It’s all about damage of endothelium of small vessels (micro-angio-pathy). This will cause red blood cells to “crash into” inflamed walls, break (hemolytic anemia) and trigger clot formation (thrombotic). Anemia will cause hypoxemia and then thrombosis leads to reduced and impaired blood flow, tissue hypoxia, infarction and a suggestive clinical picture: petechiae, purpura, pain, organ…