It’s all about damage of endothelium of small vessels (micro-angio-pathy). This will cause red blood cells to “crash into” inflamed walls, break (hemolytic anemia) and trigger clot formation (thrombotic). Anemia will cause hypoxemia and then thrombosis leads to reduced and impaired blood flow, tissue hypoxia, infarction and a suggestive clinical picture: petechiae, purpura, pain, organ…